Alexander W. Shingleton
Ph.D., University of Cambridge, 2001
39 Natural Science Building
Office Telephone: 517-353-2253
Environmental Influences on Genome Development
We study how the environment influences development to regulate morphology, and how this regulation evolves to generate diversity. We are particularly interested in how the environment influences body and organ size, using the fruit fly, Drosophila melanogaster, as a model organism. Our work integrates genetics, physiology, and evolution.
Shingleton, A.W., C.M. Estep, M.V. Driscoll, and I. Dworkin. 2009. Many ways to be small: Different environmental regulators of size generate different scaling relationships in Drosophila melanogaster. Proceedings of the Royal Society, London, Series B epub-ahead of print.
Frankino, W.A., D.J. Emlen, A.W. Shingleton. 2009. Experimental approaches to studying the evolution of morphological allometries: The shape of things to come in "Experimental Evolution". (T. Garland and M.R. Rose, Eds) University of California Press, Berkeley.
Stieper, B.C., M. Kupershtok, M.V. Driscoll, and A.W. Shingleton. 2008 Imaginal disc growth regulates the timing of metamorphosis in Drosophila melanogaster. Developmental Biology, 321, 18-26.
Shingleton, A.W., C.K. Mirth, and P.W. Bates. 2008. Developmental model of static allometry in holometabolous insects. Proceedings of the Royal Society, London. Series B, 275, 1875-1885.
Shingleton, A.W., W.A. Frankino, T. Flatt, H.F. Nijhout, and D.J. Emlen. 2007. Developmental mechanisms and the evolution of allometries. BioEssays 29, 536-548.