John P. Giesy

Professor Emeritus

Ph.D., Michigan State University, 1974
Currently at University of Saskatchewan: see Research site

Environmental Toxicology in Aquatic Ecosystems

My primary research focus is on the fates and effects of trace contaminants, especially in aquatic systems. We seek to understand the relative importance of trace contaminants such as metals, polycyclic aromatic hydrocarbons, pesticides and industrial chemicals such as PCBs and dioxins in limiting wildlife populations. We study accumulation by and effects of these classes of compounds on fish, birds and mammals. We study the biochemical mechanisms of action and determine population, community and ecosystem-level effects. Our studies are designed to separate the effects of contaminants from those of other limiting factors such as habitat, nutrition and disease. When effects are observed in field populations we design studies that involve toxicology, analytical chemistry and ecology to determine the most likely causes. Recently we have been studying the effects of chlorinated hydrocarbons on fish-eating colonial water birds, eagles and mink. Our studies take us from the laboratory to the middle of the Pacific Ocean.

Representative Publications

Knobil, E., H.A. Bern, J. Burger, D.M. Fry, J.P. Giesy, J. Gorski, C.J. Grossman, L.J. Guillette, B.S. Hulka, J.C. Lamb, J.A. McLachlan, L.A. Real, S.H. Safe, A.M. Soto, J.J. Stegeman, S.H. Swan, F.S. von Saal. 1999. Hormonally Active Agents in the Environment. Committee on Hormonally Active Agents in the Environment, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council, National Academy Press, Washington, DC. 430 p.

Kendall, R.J., R.L. Dickerson, J.P. Giesy, and W.A. Suk (Eds.). 1998. Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL, 491 p.

Villalobos, S.A., D. Papoulias, J. Meadows, A.L. Blankenship, S. D. Pastva, K. Kannan, D.E. Tillitt and J.P. Giesy. 2000. Toxic Responses of Ploychlorinated Napthalene Mixtures to Medaka (dRr Strain) After Embryonic Exposure by In ovo Microinjection: A Partial Life Cycle Assessment. Environ. Toxicol. Chem. 19: 432-440.

Khim, J.S., D.L. Villeneuve, K. Kannan, C. H. Koh, S. A. Snyder and J.P. Giesy. 1999. Alkylphenols, Polycyclic Aromatic Hydrocarbons (PAHs) and Organochlorines in Sediment from Lake Shihwa, Korea: Instrumental and Bioanalytical Characterization. Environ. Toxicol. Chem. 18: 2424-2432.

Miles-Richardson, S.R., V.J. Kramer, S.D. Fitzgerald, J. Render, S. Barbee and J.P. Giesy. 1999. Effects of Waterborne Exposure of 17a-Estradiol on Secondary Sex Characteristics and Gonads of Fat Head Minnow (Pimephales promelas). Aquatic Toxicol. 47: 129-145.

Khim, J.S., K. Kannan, D.L. Villeneuve, C. H. Koh and J.P. Giesy. 1999. Characterization and Distribution of Trace Organic Contaminants in Sediment from Masan Bay, Korea: 1. Instrumental Analyses. Environ. Sci. Technol. 33: 4199-4205.

Snyder, S.A., D. Villeneuve, D. Verbrugge and J.P. Giesy. 1999. Analytical Methods for Detection of Selected Estrogenic Compounds in Aqueous Mixtures. Environ. Sci. Technol. 33: 2814-2820.

Smeets, J.M.W., I. van Holsteijn, J.P. Giesy, W. Seinen and M. van den Berg. 1999. Estrogenic Potencies of Several Environmental Pollutants, as Determined by Vitellogenin Induction in a Carp Hepatocyte Assay (Cyprinus carptio). Toxicol. Sci. 50: 206-213.

Senthilkumar, K., C.A. Duda, D.L. Villeneuve, K. Kannan, J. Falandysz and J.P. Giesy. 1999. Butyltin Compounds in Sediment and Fish from the Southern Baltic Sea, Poland, 1997-1999. Environ. Sci. Pollut. Res. 6: 200-206.

Kramer, V.J., and J.P. Giesy. 1999. Specific Binding of Hydroxylated PCBs and Other Substances to Calf Uterine Estrogen Receptor: Structure-activity Relationships. Sci. Total. Environ. 233: 141-161.

Feyk, L.A., A.T.C. Bosveld, M. Van den Berg and J.P. Giesy. 1999. Cytochrome P450-1A Activity in Common Terns Fed Polychlorinated Biphenyls, as Measured by Caffeine Breath Tests. Environ. Toxicol. Chem. 18: 2013-2022.

Nichols. K, E. Snyder, S. Miles-Richardson, S. Pierens, S. Snyder and J.P. Giesy. 1999. Effects of Municipal Wastewater Exposure in situ on the Reproductive Physiology of the Fathead Minnow (Pimephales promelas). Environ. Toxicol. Chem. 18: 2001-2012.