Kyle E. Miller
Assistant Professor
Ph.D., Emory University, 1996
337 Natural Science Building
Office Telephone: 517-353-9283
kmiller@msu.edu
Research Website
Mitochondria Transported in Neurons
The goal of our lab is to answer the question, "How do axons grow?" We address this problem by analyzing the biogenesis, transport, and degradation of mitochondria in neurons by mathematical modeling, biophysical analysis, genetic screens, targeted gene disruption, and behavioral studies. Our integrative studies are conducted in both cultured neurons and Drosophila. Our hope is that a global understanding of the mitochondrial life cycle in neurons will lead to treatments that facilitate axonal regeneration and pooint the way to treatments for mitochondrial diseases.
Representative Publications
O'Toole, M., P. Lamoureux, and K.E. Miller. 2008. A physical model of axonal elongation: force, viscosity, and adhesions govern the mode of outgrowth. Biophys J 94(7): 2610-2620.
Miller, K.E. and S.R. Heidemann. 2008. What is slow axonal transport? Exp Cell Res 314(10): 1981-1990.
O'Toole, M., R. Latham, R.M. Baqri, and K.E. Miller. 2008. Modeling mitochondrial dynamics during in vivo axonal elongation. J Theor Biol 255(4): 369-377.
Miller, K.E. and M.P. Sheetz. 2006. Direct evidence for coherent low velocity axonal transport of mitochondria. J Cell Biol 173(3): p. 373-81.
Miller, K.E. and M.P. Sheetz. 2004. Axonal mitochondrial transport and potential are correlated. J Cell Sci 117(Pt 13): p. 2791-2804.